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Furthermore, the piecemeal necrosis, focal lytic necrosis, apoptosis, and focal inflammation, disturbed cell proliferation (Ki-67-staining), cytoskeletal structure in the hepatic stellate cell (α-SMA staining), and collagen presentation (Mallory staining) were all counteracted, providing evidence that BPC 157 may affect both liver fibrosis and portal hypertension[150]